Combine chicken, buttermilk and hot sauce in a bowl or zip-top bag. Marinate for 1-24 hours in the fridge.
In a shallow dish, whisk together the flour, seasoning salt, garlic powder, onion powder, Italian seasoning and cayenne.
Working in batches, remove chicken from marinade and dredge in seasoned flour until fully coated.
Arrange chicken pieces in a single layer in the air fryer basket, ensuring they don't touch.
Air fry at 390°F for 25 minutes, flipping and spraying any dry flour spots with oil at the 13 minute mark.
Chicken is done when it reaches an internal temperature of 165°F.
Let chicken rest 5 minutes before serving hot. Enjoy!