Season the tomato slices all over with salt and pepper.
Set up three shallow bowls - one with the flour, one with the beaten eggs, and one with the cornmeal, panko, paprika and cayenne mixed together.
Dredge each tomato slice first in the flour until fully coated, then in the egg mixture, letting any excess drip off. Finally coat in the cornmeal/panko mixture, pressing gently to adhere. Place on a baking sheet or plate and repeat with remaining slices.
In a large skillet, heat 1/2-inch of oil over medium-high heat until shimmering.
Working in batches, fry the tomatoes for 2-3 minutes per side until deep golden brown. Transfer to a paper towel-lined plate.
Serve the fried green tomatoes warm with remoulade, ranch or your desired dipping sauce!