Preheat oven to 350°F. Grease a 9x13 baking dish and set aside.
In a skillet over medium-high heat, cook the ground beef until browned and crumbly. Drain excess fat.
Add the diced tomatoes, diced tomatoes with green chiles, tomato paste, garlic powder, onion powder, salt and pepper. Bring to a simmer and cook for 15-20 minutes, stirring occasionally.
Meanwhile, cook the egg noodles according to package instructions until al dente. Drain and toss with the sour cream until fully coated.
Spread the creamy noodles in an even layer in the prepared baking dish. Top with the beef and tomato sauce, then sprinkle the shredded cheeses evenly over top.
Bake for 20-25 minutes until hot, bubbly, and the cheese is melted and lightly browned on top.
Let stand 5 minutes before serving. Enjoy!