Preheat oven to 375°F (190°C). Line a sheet pan with foil or parchment and spray lightly.
In a large bowl, combine ground beef, eggs, panko, onion, half the BBQ sauce, Worcestershire, garlic powder, salt, and pepper.
Mix gently until everything is combined.
Shape into a rectangle on the sheet pan, about 1½ inches thick.
Bake for 45 minutes.
Remove from oven, brush with remaining BBQ sauce, and return to bake for another 15 minutes, or until internal temperature reaches 165°F.
Let rest for 5–10 minutes before slicing and serving.