Pat pork tenderloin dry with paper towels. Season with salt and pepper.
Mix brown sugar, Dijon mustard, garlic powder, onion powder, and smoked paprika in a bowl.
Rub brown sugar mixture all over pork tenderloin.
Lay bacon slices slightly overlapping on clean surface.
Place seasoned pork on bacon and wrap carefully.
Transfer to slow cooker seam-side down.
Cover and cook on LOW 6-7 hours until pork reaches 145°F.
Remove and let rest 10 minutes before slicing.